| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | 20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid |
| 生化机理 | Description:IC50 Value: N/A20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450-derived arachidonic acid metabolite that has been shown to increase smooth muscle contractions and proliferation, stimulate endothelial dysfunction and activation and promote hypertension.in vitro: Addition of 20-HETE to the bath (1-100 nM), reduced the frequency of opening of the large-conductance Ca(2+)-activated K+ channel recorded using cell-attached patches on VSM [1]. In kidney, 20-HETE induces diuresis by inhibiting Na+-K+-ATPase in proximal tubules and Na+/K+/Cl+ cotransporter in the thick ascending limb of Henle's loop [2].in vivo: In Cyp4a14(-/-) mice, which display androgen-driven and 20-HETE-dependent hypertension, treatment with20-HETE antagonist abolished remodeling of renal resistance arteries measured as media thickness (24±1 vs. 15±1μm) and M/L (0.29±0.03 vs. 0.17±0.01) [4]. The transgenic mice |
| 别名 | ;20-Hydroxyarachidonic acid，20-HETE |
20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸(20-HETE)
20-HETE （订货以英文为准）
编号：H126988
CAS号：79551-86-3
分子式：C20H32O3
分子量：320.47
| 产品名称 | 20-HETE |
| 中文名称 | 20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸(20-HETE) |
| CAS号 | 79551-86-3 |
| MDL编码 | MFCD00171542 |
| 分子式（M.F.） | C20H32O3 |
| 分子量（M.W.） | 320.47 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Warning |
| 危害声明 | H319-H413 |
| 警示性声明 | P305 + P351 + P338 |
| WGK德国 | 3 |
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