| 溶解性 | DMSO <1 mg/mL Water 100 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A specific CXCR4 antagonist. |
| 产品介绍 | Plerixafor 8HCl (AMD3100 8HCl)是Plerixafor的盐酸盐，是CXCR4趋化因子受体拮抗剂，作用于CXCR4和CXCL12调节的趋化性， IC50分别为44 nM和5.7 nM。 |
| 备注 | Plerixafor 8HCl (AMD3100 8HCl) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
| 生化机理 | AMD3100 octahydrochloride is a selective bicyclam derivative which functions as a stem cell mobiliser via blocking the CXCR4 chemokine receptor. Studies suggest that AMD3100 octahydrochloride causes the rapid movement of stem cells out of bone marrow via blocking the CXCR4 receptor. Since the CXCR4 receptor is responsible for regulating metastasis in chemoresistant melanoma cells, blocking this receptor can possibly reduce the metastasis of melanoma cells. In addition, studies indicate that AMD3100 octahydrochloride can inhibit the replication of human immunodeficiency virus in vitro by blocking the entry of the virus into cells. Furthermore, AMD3100 octahydrochloride can also reduce the number of human CD4+ T cells. |
| 别名 | 普乐沙福八盐酸盐;AMD3100 octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride;1,1′-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride |
普乐沙福八盐酸盐(AMD3100 8HCl)
Plerixafor 8HCl (AMD3100 8HCl) （订货以英文为准）
编号：P129846
CAS号：155148-31-5
分子式：C28H62CL8N8
分子量：794.47
| 产品名称 | Plerixafor 8HCl (AMD3100 8HCl) |
| 中文名称 | 普乐沙福八盐酸盐(AMD3100 8HCl) |
| CAS号 | 155148-31-5 |
| 分子式（M.F.） | C28H62CL8N8 |
| 分子量（M.W.） | 794.47 |
| 储存条件 | -20°C储存 |
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