| 沸点 | ~443.81° C at 760 mmHg |
| 熔点 | 219-220° C |
| 折光率 | 1.61 |
| 溶解性 | DMSO 36 mg/mL Water <1 mg/mL Ethanol 3 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A protein tyrosine kinase inhibitor with potent effects on TrkA |
| 产品介绍 | AG879是酪氨酸激酶的抑制剂，能够抑制TrKA的磷酸化，但不能抑制TrKB 和TrKC，也是高选择性的ErbB2激酶抑制剂。 |
| 备注 | Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR. |
| 生化机理 | Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA. This product reportedly inhibits NGF-induced PLC-γ 1 phosphorylation and phosphatidylinositol-3 kinase activation. Has been shown in lab studies to disrupt Sertoli cell aggregation and stop androgen-induced cell proliferation. AG 879 also displays anti-cancer effects by inhibiting the expression of RAF-1 gene encoding MAP kinase activity necessary for human breast cancer cell proliferation. Shown to inhibit Neu (HER-2 or ERBB2) expression and reduced tumor sizes in mice leukemia cells. Tyrphostin AG 879 is an inhibitor of Flk-1. |
| 别名 | AG 879；AG-879；AG879;AG 879；AG-879；AG879； α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide； (E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide |
Tyrphostin AG 879 酪氨酸激酶的抑制剂
Tyrphostin AG 879 （订货以英文为准）
编号：T129799
CAS号：148741-30-4
分子式：C18H24N2OS
分子量：316.46
| 产品名称 | Tyrphostin AG 879 |
| 中文名称 | Tyrphostin AG 879 酪氨酸激酶的抑制剂 |
| CAS号 | 148741-30-4 |
| MDL编码 | MFCD00236450 |
| 分子式（M.F.） | C18H24N2OS |
| 分子量（M.W.） | 316.46 |
| 储存条件 | -20°C储存 |
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