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埃格列净

PF-04971729 （订货以英文为准）

编号：P127306
CAS号：1210344-57-2
分子式：C22H25CLO7
分子量：436.88
货号 品牌 包装 目录价 您的价格 库存 数量 购买
P127306-10mg 阿拉丁 10mg ¥2059.90
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P127306-50mg 阿拉丁 50mg ¥7209.90
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P127306-5mg 阿拉丁 5mg ¥1273.90
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产品名称 PF-04971729
中文名称 埃格列净
CAS号 1210344-57-2
分子式（M.F.） C22H25CLO7
分子量（M.W.） 436.88
储存条件 -20°C储存;充氩
溶解性DMSO
存贮条件储存温度-20°C
产品介绍PF-04971729(Ertugliflozin)是钠离子依赖的葡萄糖协同转运蛋白2（SGLT2）抑制剂。
生化机理PF-04971729, a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2, is currently in phase 2 trials for the treatment of diabetes mellitus. Inhibitory effects against the organic cation transporter 2-mediated uptake of [14C]metformin by PF-04971729 also were very weak (IC50 900μM).The disposition of PF-04971729, an orally active selective inhibitor of the sodium-dependent glucose cotransporter 2, was studied after a single 25-mg oral dose of [14C]-PF-04971729 to healthy human subjects. The absorption of PF-04971729 in humans was rapid with a Tmax at ~ 1.0 h. Of the total radioactivity excreted in feces and urine, unchanged PF-04971729 collectively accounted for ~ 35.3% of the dose, suggestive of moderate metabolic elimination in humans.
别名1,6-脱水-1-C-[4-氯-3-[(4-乙氧基苯基)甲基]苯基]-5-C-(羟基甲基)-beta-L-艾杜糖;PF04971729;PF 04971729;Ertugliflozin;PF04971729;PF 04971729;1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-beta-L-idopyranose
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