| 溶解性 | DMSO 84 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Duvelisib (IPI-145) 是PI3K δ和γ高度选择性抑制剂, Ki和IC50分别为23 pM/243 pM和1 nM/50 nM。 |
| 生化机理 | IPI-145 suppresses murine/human B-cell proliferation with EC50 of 0.5 nM/0.5 nM and also inhibits human T-cell proliferation with EC50 of 9.5 nM . IPI-145 (10 mg/kg, p.o.) shows well pharmacokinetics with Cmax and AUC of 390 ng/mL and 137 ng/mL in mouse and rat. IPI-145 (10 mg/kg) is active in murine DTH model with ~50% ear swelling. IPI-145 (10 mg/kg) demonstrates dose-dependent effect in rat collagen induced arthritis (CIA) model. IPI-145 prevents inflammation and protects joint bone and cartilage in the rat CIA model. IPI-145 (10 mg/kg,QD) demonstrates activity in rat adjuvant induced polyarthritis model. |
| 别名 | IPI 145; IPI145; INK 1197; INK-1197; 8-chloro-2-phenyl-3-((1s)-1-(9h-purin-6-ylamino)ethyl)-1(2h)-isoquinolinone |
Duvelisib (IPI-145, INK1197),P100δ抑制剂
Duvelisib (IPI-145, INK1197) （订货以英文为准）
编号：I126464
CAS号：1201438-56-3
分子式：C22H17CLN6O
分子量：416.86
| 产品名称 | Duvelisib (IPI-145, INK1197) |
| 中文名称 | Duvelisib (IPI-145, INK1197),P100δ抑制剂 |
| CAS号 | 1201438-56-3 |
| 分子式（M.F.） | C22H17CLN6O |
| 分子量（M.W.） | 416.86 |
| 储存条件 | -20°C储存 |
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