DY131,ERRβ和ERRγ激动剂

DY131 (订货以英文为准)

编号:D126355
CAS号:95167-41-2
分子式:C18H21N3O2
分子量:311.38
货号 品牌 包装 目录价 您的价格 库存 数量 购买
D126355-10mg 阿拉丁 10mg ¥694.90
D126355-250mg 阿拉丁 250mg ¥6235.90
D126355-50mg 阿拉丁 50mg ¥2465.90
产品名称 DY131
中文名称 DY131,ERRβ和ERRγ激动剂
CAS号 95167-41-2
分子式(M.F.) C18H21N3O2
分子量(M.W.) 311.38
储存条件 2-8°C储存
折光率1.57
溶解性DMSO 100 mg/ml Ethanol 10 mg/ml
存贮条件储存温度2-8℃
密度1.1200
应用A novel selective agonist at ERRβ and ERRγ
产品介绍DY131(GSK 9089)是ERRβ和ERRγ选择性激动剂,对ERRα,ERα和ERβ的活性极低。
生化机理DY131, a selective ERRγ agonist, could potentiate the ERRγ-induced growth inhibition in LNCaP- ERRγ and DU145- ERRγ cells in a dose-dependent manner compared with respective parental cells. DY131 inhibited the growth of the ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells. DY131 had no effect on the structurally related receptors ERRα or the estrogen receptors alpha and beta (ERalpha/beta). DY131 appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists.
别名GSK 9089;DY-131;DY 131;GSK9089;GSK-9089;GSK 9089;DY-131;DY 131;GSK9089;GSK-9089;4-hydroxybenzoic acid 2-((4-(diethylamino)phenyl)methylene)hydrazide;
个人防护设备Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国3
搜索质检报告(COA)
搜索MSDS
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