| 敏感性 | 对热、光和空气敏感 |
| 溶解性 | Soluble in DMSO (>25 mg/ml), ethanol (15 mg/ml), methanol, dichloromethane, DMF (~25 mg/ml), and 1:3 DMF:PBS (pH 7.2) (~0.25 mg/ml). Insoluble in water, and sparingly soluble in aqueous buffers. |
| 存贮条件 | 储存温度 2-8°C ,充氩储存 |
| 应用 | An anti-inflammatory agent and NFκB inhibitor |
| 产品介绍 | BAY 11-7082是一种NF-κB抑制剂，抑制TNFα诱导的IκBα磷酸化，IC50为10 μM。同时对泛素化系统的组分也有抑制作用。 |
| 备注 | BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
| 生化机理 | BAY 11-7082, a potential anti-inflammatory agent, is an irreversible inhibitor of IKK α and phosphorylation of cytokine-inducible IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-α, NFKBIA; IC50=10 μM). In intact HUVECs, it inhibits TNFα-induced phosphorylation and degradation of IκBa (NFKBIA) without affecting constitutive phosphorylation. Inhibition of ιBα phosphorylation and degradation results in the inactivation of NFκB and thereby inhibits the expression of endothelial-leukocyte adhesion molecules: E-selectin, VCAM-1 and ICAM-11. BAY 11-7082 has also demonstrated stimulation of the stress-activated protein kinases, p38 and JNK-1. |
| 别名 | (E)-3-(对甲苯磺酰基)丙烯腈; (E)-3-甲苯磺酰基丙烯腈;(2E)-3-[(4-甲基苯基)磺酰基]-2-丙烯腈;(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile;(E)-3-Tosylacrylonitrile;(E)-3-(p-Toluenesulfonyl)acrylonitrile |
BAY 11-7082,IκBα激酶抑制剂
BAY 11-7082 （订货以英文为准）
编号：B129693
CAS号：19542-67-7
分子式：C10H9NO2S
分子量：207.25
| 产品名称 | BAY 11-7082 |
| 中文名称 | BAY 11-7082,IκBα激酶抑制剂 |
| CAS号 | 19542-67-7 |
| 分子式（M.F.） | C10H9NO2S |
| 分子量（M.W.） | 207.25 |
| 储存条件 | 2-8°C储存;充氩 |
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