溶解性 | DMSO 71 mg/mL Water <1 mg/mL Ethanol 3 mg/mL |
存贮条件 | 储存温度-20°C |
产品介绍 | VS-5584 (SB2343)是PI3K/mTOR双重抑制剂,对mTOR和PI3Kα/β/δ/γ的IC50分别为3.4 nM和2.6-21 nM。 |
生化机理 | VS-5584 (formerly SB-2343), is a novel, low-molecular weight compound with equivalent potent activity against mTOR (IC(50) = 37 nmol/L) and all class I phosphoinositide 3-kinase (PI3K) isoforms IC(50): PI3Kα = 16 nmol/L; PI3Kβ = 68 nmol/L; PI3Kγ = 25 nmol/L; PI3Kδ = 42 nmol/L, without relevant activity on 400 lipid and protein kinases. VS-5584 shows robust modulation of cellular PI3K/mTOR pathways, inhibiting phosphorylation of substrates downstream of PI3K and mTORC1/2. Antitumor agent. |
别名 | VS-5584;VS5584;VS 5584;5-[8-甲基-9-异丙基-2-(4-吗啉基)-9H-嘌呤-6-基]-2-嘧啶胺;SB-2343;;SB2343;SB 2343;5-[8-Methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine |
VS-5584(SB2343),PI3K/mTOR双重抑制剂
VS-5584 (SB2343) (订货以英文为准)
编号:V125616
CAS号:1246560-33-7
分子式:C17H22N8O
分子量:354.41
产品名称 | VS-5584 (SB2343) |
中文名称 | VS-5584(SB2343),PI3K/mTOR双重抑制剂 |
CAS号 | 1246560-33-7 |
分子式(M.F.) | C17H22N8O |
分子量(M.W.) | 354.41 |
储存条件 | -20°C储存 |
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