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H-1152,ROCK 抑制剂

H-1152 （订货以英文为准）

编号：H125533
CAS号：451462-58-1
分子式：C16H21N3O2S
分子量：319.42
货号 品牌 包装 目录价 您的价格 库存 数量 购买
H125533-5mg 阿拉丁 5mg ¥1113.90
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H125533-25mg 阿拉丁 25mg ¥5046.90
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H125533-100mg 阿拉丁 100mg ¥10299.90
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产品名称 H-1152
中文名称 H-1152,ROCK 抑制剂
CAS号 451462-58-1
分子式（M.F.） C16H21N3O2S
分子量（M.W.） 319.42
储存条件 2-8°C储存
溶解性25°C: DMSO
存贮条件储存温度2-8℃
应用A cell permeable, highly specific, and potent ATP-competitive inhibitor of ρ-kinase inhibitor。
产品介绍H-1152是特异的高活性Rho激酶抑制剂，可渗透入细胞膜，Ki为1.6 nM，对其它丝氨酸/苏氨酸激酶抑制性极低。
生化机理H-1152 is a selective ATP-competitive inhibitor of rho-kinase (ROCK) inhibitor, cell permeable, highly specific, and potent (Ki = 1.6 nM). Exhibits weaker affinity for other serine/threonine kinases (Ki = 630 nM for PKA, 9.27mM for PKC and 10.1 mM for MLCK) and is more potent and selective than Y-27632. Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid and inhibits EP3-stimulated NO formation. H-1152 . dihydrochloride prevents fragmentation of apoptotic cells. Relieves neuropathic pain.
别名H 1152;H1152；4-甲基-5-{[(2S)-2-甲基-1,4-二氮杂环庚-1-基]磺酰基}异喹啉;H 1152;H1152; 4-methyl-5-{[(2s)-2-methyl-1,4-diazepan-1-yl]sulfonyl}isoquinoline ;(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine
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