| 溶解性 | Soluble in DMSO (13 mg/ml) at 25 °C, water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C |
| 存贮条件 | 储存温度-20°C |
| 应用 | An EGFR phosphorylation inhibitor |
| 产品介绍 | WZ4002是一种新型的，突变选择性的EGFR抑制剂，作用于EGFR(L858R)/(T790M)时IC50为2 nM/8 nM；对ERBB2磷酸化(T798I)没有抑制作用。 |
| 备注 | WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM; does not inhibit ERBB2 phosphorylation (T798I). |
| 生化机理 | WZ 4002 is an inhibitor of EGFR phosphorylation in a variety of cancer cell lines including NIH-3T3 and H1975 cells. WZ 4002 is a potent inhibitor of EGFR, exhibiting an IC50 = 2 nM. This induces apoptosis in the cell due to the blocking of signal transduction from EGFR. |
| 别名 | WZ 4002; WZ-4002; N-[3-[[5-氯-2-[[2-甲氧基-4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氧基]苯基]-2-丙烯酰胺;N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;WZ 4002; WZ-4002 |
WZ4002
WZ4002 （订货以英文为准）
编号：W127713
CAS号：1213269-23-8
分子式：C25H27CLN6O3
分子量：494.97
| 产品名称 | WZ4002 |
| 中文名称 | WZ4002 |
| CAS号 | 1213269-23-8 |
| 分子式（M.F.） | C25H27CLN6O3 |
| 分子量（M.W.） | 494.97 |
| 储存条件 | -20°C储存 |
搜索质检报告(COA)
搜索MSDS
相关产品
¥ 1890.00
CR-070S-1台
¥ 98.00
sh5670-1片
¥ 98.00
sh024578-1片
¥ 120.00
sh02432-250mL
¥ 120.00
sh024431-250mL
¥ 120.00
sh024430-250mL
党沛 
