溶解性 | Soluble in DMSO (90 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), and ethanol (< 1 mg/ml at 25 °C). |
存贮条件 | 储存温度-20°C |
备注 | AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. |
生化机理 | AZ628 is a potent Raf kinase inhibitor with IC50 values of 105 nM for wild-type B-raf, 34 nM for Raf-B V600E and 29 nM for wild-type c-Raf-1. AZ628 is a type II inhibitor that binds to the catalytically inactive Asp-Phe-Gly (DFG)-out configuration. |
别名 | AZ-628; 3-(1-氰基-1-甲基乙基)-N-[3-[(3,4-二氢-3-甲基-4-氧代-6-喹唑啉基)氨基]-4-甲基苯基]苯甲酰胺; 3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-benzamide ;AZ-628 |
AZ 628,适用于BRAF,BRAFV600E和c-Raf的新型Pan-Raf抑制剂
AZ 628 (订货以英文为准)
编号:A129605
CAS号:878739-06-1
分子式:C27H25N5O2
分子量:451.52
产品名称 | AZ 628 |
中文名称 | AZ 628,适用于BRAF,BRAFV600E和c-Raf的新型Pan-Raf抑制剂 |
CAS号 | 878739-06-1 |
分子式(M.F.) | C27H25N5O2 |
分子量(M.W.) | 451.52 |
储存条件 | -20°C储存 |
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