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CHR-6494,haspin 抑制剂

CHR-6494 （订货以英文为准）

编号：C124894
CAS号：1333377-65-3
分子式：C16H16N6
分子量：292.34
货号 品牌 包装 目录价 您的价格 库存 数量 购买
C124894-10mg 阿拉丁 10mg ¥834.90
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C124894-5mg 阿拉丁 5mg ¥446.90
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C124894-50mg 阿拉丁 50mg ¥3089.90
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C124894-100mg 阿拉丁 100mg ¥5397.90
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C124894-25mg 阿拉丁 25mg ¥1699.90
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产品名称 CHR-6494
中文名称 CHR-6494,haspin 抑制剂
CAS号 1333377-65-3
分子式（M.F.） C16H16N6
分子量（M.W.） 292.34
储存条件 -20°C储存
溶解性DMSO
存贮条件储存温度2-8℃
生化机理Haspin is a serine/threonine kinase that phosphorylates Thr-3 of histone H3 in mitosis that has emerged as a possible cancer therapeutic target. CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity.
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