| 溶解性 | DMSO 127 mg/mL Water <1 mg/mL Ethanol 127 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Phase 3. |
| 生化机理 | Lonafarnib is a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. |
| 别名 | SCH66336;1-Piperidinecarboxamide, 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-;SCH66336;1-Piperidinecarboxamide, 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]- |
洛那法尼
Lonafarnib （订货以英文为准）
编号：L125407
CAS号：193275-84-2
分子式：C27H31BR2CLN4O2
分子量：638.82
| 产品名称 | Lonafarnib |
| 中文名称 | 洛那法尼 |
| CAS号 | 193275-84-2 |
| 分子式（M.F.） | C27H31BR2CLN4O2 |
| 分子量（M.W.） | 638.82 |
| 储存条件 | -20°C储存 |
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