| 溶解性 | Soluble in DMSO (0.25 mg/ml), and DMF (0.25 mg/ml). |
| 存贮条件 | 储存温度-20°C |
| 应用 | An inhibitor of SIRT1 and SIRT2. |
| 产品介绍 | Tenovin-1防止MDM2介导的p53的降解，涉及泛素化途径，通过抑制SirT1和SirT2的蛋白脱乙酰活性。 |
| 备注 | Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. |
| 生化机理 | Tenovin-1 is a compound that belongs to the class of Tenovins, and inhibits SIRT1 and SIRT2. SIRT1 and SIRT2 are protein-deacetylases and are members of the NAD+-dependent class III histone deacetylases. Tenovin-1 has been shown to activate and elevate acetylated p53 levels, induce apoptosis in vitro, and acetylate histone H4. Studies report that the water solubility of Tenovin-1 was increased by attaching a solubilizing group to the R2 position, creating a new Tenovin, Tenovin-6. Tenovin-1 is an activator of p21 and p53. |
| 别名 | N-[[[4-(乙酰氨基)苯基]氨基]硫代甲酰]-4-叔丁基苯甲酰胺;Tenovin 1;Tenovin 1;N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide |
Tenovin-1,p53激活剂
Tenovin-1 （订货以英文为准）
编号：T125146
CAS号：380315-80-0
分子式：C20H23N3O2S
分子量：369.48
| 产品名称 | Tenovin-1 |
| 中文名称 | Tenovin-1,p53激活剂 |
| CAS号 | 380315-80-0 |
| 分子式（M.F.） | C20H23N3O2S |
| 分子量（M.W.） | 369.48 |
| 储存条件 | -20°C储存 |
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