| 熔点 | 260°C |
| 敏感性 | 对光线敏感 |
| 溶解性 | Soluble in water. |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.5100 |
| 应用 | Na+, K+-ATPase的典型抑制剂,抑制阳离子输送.Cardiac glycoside.生化研究Ouabain octahydrate has been used:· to determine the effect of salt and ammonia in the external environment on the rate of activity of Na+ /K+ in either silver or golden perch· in the basolateral compartment to induce maximal baseline short-circuit current in rat fetal distal lung epithelial (FDLE) cells· as an Na+/K+ ATPase inhibitor to study the relation between blister formation and adenosine triphosphate (ATP) dependent maintenance of plasma membrane homeostasis |
| 产品介绍 | Ouabain is a steroid hormone, naturally present in mammals. |
| 生化机理 | Cardiac glycoside, inhibits Na(+)/K(+) ATPase, regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1. Ouabain resistance is associated with appearance of Na(+)/K(+) ATPase isoforms with low binding affinity. Ouabain has its specific binding site on integral proteins of the plasma membrane. Heart disease is treated using ouabain derivatives.Increased ouabain production is observed during exercise in humans. Abnormally high levels of ouabain are indicated in congestive heart failure and hypertension. Ouabain signalling affects intracellular calcium levels, which is known to activate nuclear factor κB (NFκB). |
| 别名 | 毒毛旋花苷G ;羊角拗质 ;十水合乌本苷;1β,3β,5β,11α,14,19-Hexahydroxycard-20（22）-烯醇内酯-3-（6-脱氧-α-L-甘露糖苷）, G-毒毛花苷, 乌本苷;1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside)AcocantherineG-StrophanthinG-Strophantin octahydrate |
Ouabain octahydrate
Ouabain octahydrate （订货以英文为准）
编号：O112990
CAS号：11018-89-6
分子式：C29H44O12.8H2O
分子量：728.77
| 产品名称 | Ouabain octahydrate |
| 中文名称 | Ouabain octahydrate |
| CAS号 | 11018-89-6 |
| 分子式（M.F.） | C29H44O12.8H2O |
| 分子量（M.W.） | 728.77 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs06.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H301,H331,H373 |
| 警示性声明 | P261-P301 + P310-P311 |
| WGK德国 | 3 |
| 风险声明 (欧洲) | 23/25,33 |
| 安全声明（欧洲） | 45 |
| 危害码（欧洲） | T |
| 是否危化品 | 一般危化品 |
| UN代码 | 1544 |
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