| 溶解性 | DMSO 96 mg/mL Water <1 mg/mL Ethanol 96 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | BMN 673是一种新型的PARP抑制剂，IC50为0.58 nM，也有效抑制PARP-2，但不抑制PARG，对PTEN突变型高度敏感。 |
| 备注 | BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 1. |
| 生化机理 | BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. |
| 别名 | LT-673;(8S,9R)-5-氟-8-(4-氟苯基)-2,7,8,9-四氢-9-(1-甲基-1H-1,2,4-三唑-5-基)-3H-吡啶并[4,3,2-de]酞嗪-3-酮;BMN673; BMN 673;(8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazine-3-one |
BMN 673
BMN 673 （订货以英文为准）
编号：B127705
CAS号：1207456-01-6
分子式：C19H14F2N6O
分子量：380.35
| 产品名称 | BMN 673 |
| 中文名称 | BMN 673 |
| CAS号 | 1207456-01-6 |
| 分子式（M.F.） | C19H14F2N6O |
| 分子量（M.W.） | 380.35 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H302-H341-H350-H360 |
| 警示性声明 | P201-P281-P308 + P313 |
| WGK德国 | 3 |
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