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尼可地尔

Nicorandil （订货以英文为准）

编号：N129566
CAS号：65141-46-0
分子式：C8H9N3O4
分子量：211.17
货号 品牌 包装 目录价 您的价格 库存 数量 购买
N129566-1g 阿拉丁 1g ¥66.90
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N129566-25g 阿拉丁 25g ¥504.90
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N129566-100g 阿拉丁 100g ¥1719.90
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N129566-5g 阿拉丁 5g ¥126.90
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产品名称 Nicorandil
中文名称 尼可地尔
CAS号 65141-46-0
分子式（M.F.） C8H9N3O4
分子量（M.W.） 211.17
储存条件 -20°C储存
溶解性Soluble in water (4 mg/ml), DMSO (>25 mg/ml), ethanol, ether, and methanol.
应用A small molecule KATP (Kir6) channel opener and NO donor
产品介绍Nicorandil 钾离子通道活化剂.
备注Nicorandil is potassium channel activator.
生化机理Nicorandil is a small molecule KATP (Kir6) channel opener, producing relaxation of coronary vascular smooth muscle. Specific binding of Nicorandil to the C-terminus of the SUR2B K(ATP) channel generates K+ flux and hyperpolarization of the surface membrane, producing consequent closure of voltage-dependent ion channels and reduction of intracellular free Ca2+. Nicorandil stimulates guanylate cyclase and increases cyclic GMP levels in correlation with the activation of K(ATP) channels. Nicorandil is also described to suppress mitochondrial permeability transition triggered by oxidative stress resulting from ischemia-reperfusion, preventing mitochondrial calcium uptake/overload and oxidative damage. Nicorandil has also been shown to serve as a nitric oxide donor.
别名尼可地尔;烟浪丁;硝烟酯;2-(吡啶基-3-甲酰胺)乙基硝酸盐;N-[2-(硝氧基)乙基]吡啶-3-甲酰胺;SG-75;Sigmart;Zynicor;Ikorel;2-(Pyridine-3-carbonylamino)ethyl nitrate;2-Nicotinamidoethyl nitrate;N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
标识符号https://www.aladdin-e.com/images/ghs/ghs05.jpg,https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs09.jpg
信号词Danger
危害声明H302-H315-H318-H335-H400
警示性声明P261-P273-P280-P305 + P351 + P338
WGK德国3
搜索质检报告(COA)
搜索MSDS
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