| 溶解性 | Soluble in DMSO (55 mg/ml at 25 °C), ethanol (32 mg/ml at 25 °C), and water (slightly at 25 °C). |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A selective and ATP-competitive Pim kinase inhibitor |
| 产品介绍 | SMI-4a是一种有效的Pim1抑制剂，IC50为17 nM，作用于Pim-2适度有效，抑制其他丝/苏氨酸或酪氨酸激酶作用不显著。 |
| 备注 | SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modest potent to Pim-2, does not significantly inhibit other serine/threonine- or tyrosine-kinases. |
| 生化机理 | TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC50 values = 24 and 100 nM for Pim-1 and Pim-2, respectively). TCS PIM-1 4a has been shown to display selectivity over a panel of approximately 50 other kinases tested. This compound also exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro. TCS PIM-1 4a is an inhibitor of Aldose Reductase and Cox-2 |
| 别名 | (5Z)-5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮;SMI 4a;(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione; (Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione;TCS PIM-1 4a |
SMI-4a,ATP竞争性Pim激酶抑制剂
SMI-4a （订货以英文为准）
编号：T125988
CAS号：438190-29-5
分子式：C11H6F3NO2S
分子量：273.23
| 产品名称 | SMI-4a |
| 中文名称 | SMI-4a,ATP竞争性Pim激酶抑制剂 |
| CAS号 | 438190-29-5 |
| MDL编码 | MFCD01152003 |
| 分子式（M.F.） | C11H6F3NO2S |
| 分子量（M.W.） | 273.23 |
| 储存条件 | 2-8°C储存 |
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