| 溶解性 | DMSO 87 mg/mL Water <1 mg/mL Ethanol 2 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | Sotrastaurin is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM; inactive to PKCζ. Phase 1/2. |
| 生化机理 | Sotrastaurin, a first-in-class protein kinase C (PKC) inhibitor, is aiming to become the first oral treatment that inhibits T-cell activation since the introduction of calcineurin inhibitors. T-cell activation is an early step in autoimmune diseases such as psoriasis and is also essential for the rejection of transplanted organs. Sotrastaurin blocks a pathway critical to T-cell activation and has shown promise in organ transplantation as well as in autoimmune disorders. Sotrastaurin is developed for the potential treatment of psoriatic skin lesions and graft rejection. |
| 别名 | 3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione;3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione |
Sotrastaurin,泛PKC抑制剂
Sotrastaurin （订货以英文为准）
编号：S125985
CAS号：425637-18-9
分子式：C25H22N6O2
分子量：438.49
| 产品名称 | Sotrastaurin |
| 中文名称 | Sotrastaurin,泛PKC抑制剂 |
| CAS号 | 425637-18-9 |
| 分子式（M.F.） | C25H22N6O2 |
| 分子量（M.W.） | 438.49 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs06.jpg |
| 信号词 | Danger |
| 危害声明 | H300 |
| 警示性声明 | P264;P301+P310 |
| 个人防护设备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| RTECS | UY8587000 |
| WGK德国 | 3 |
| 风险声明 (欧洲) | R25 |
| 安全声明（欧洲） | S36/37/39;S45 |
| 危害码（欧洲） | T |
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