Enzastaurin(LY317615),PKCβ抑制剂

Enzastaurin (LY317615) (订货以英文为准)

编号:E125760
CAS号:170364-57-5
分子式:C32H29N5O2
分子量:515.61
货号 品牌 包装 目录价 您的价格 库存 数量 购买
E125760-250mg 阿拉丁 250mg ¥1450.90
E125760-50mg 阿拉丁 50mg ¥503.90
E125760-10mg 阿拉丁 10mg ¥148.90
产品名称 Enzastaurin (LY317615)
中文名称 Enzastaurin(LY317615),PKCβ抑制剂
CAS号 170364-57-5
MDL编码 MFCD11040980
分子式(M.F.) C32H29N5O2
分子量(M.W.) 515.61
储存条件 -20°C储存
敏感性对湿度敏感
溶解性Soluble in DMSO (30 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), ethanol (< 1 mg/ml at 25 °C), DMF (~16.6 mg/ml), and 1:3 solution of DMF:PBS(pH 7.2) (~0.25 mg/ml).
存贮条件储存温度-20°C
应用A potent inhibitor of PKCβ, PKCα, PKCγ and PKCε.
产品介绍Enzastaurin (LY317615)是一种有效的PKCβ选择性抑制剂,IC50为6 nM,比对PKCα, PKCγ和PKCε的作用强6到20倍。
备注Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Phase 3.
生化机理Enzastaurin (LY317615) is a potent PKC beta inhibitor for PKCβ, PKCα, PKCγ and PKCε with IC50 of 6 nM, 39 nM, 83 nM and 110 nM, respectively. Enzastaurin inhibits growth in all MM cell lines investigated, including MM.1S, MM.1R, RPMI 8226 (RPMI), RPMI-Dox40 (Dox40), NCI-H929, KMS-11, OPM-2, and U266, with IC50 values ranging from 0.6 to 1.6 μM. Enzastaurin induces apoptosis and suppresses proliferation in cultured tumor cells, including malignant lymphocytes of CTCL. Enzastaurin also suppresses the phosphorylation of GSK3βser9, ribosomal protein S6S240/244, and AKTThr308
别名恩扎妥林;因扎妥雷;LY 317615; 3-(1-甲基-1H-吲哚-3-基)-4-(1-(1-(2-吡啶甲基)-4-哌啶基)-1H-吲哚-3-基)-1H-吡咯-2,5-二酮;LY317615; LY-317615; LY 317615;D04014;3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
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