货号	品牌	包装	目录价	您的价格
E107854-0.5mg	阿拉丁	0.5mg	¥419.00	请登录
E107854-5mg	阿拉丁	5mg	¥2523.90	请登录
E107854-2.5mg	阿拉丁	2.5mg	¥1549.00	请登录
E107854-500UG	阿拉丁	500UG	¥1870.00	请登录
E107854-1mg	阿拉丁	1mg	¥720.90	请登录

产品名称	Exendin-4
中文名称	艾塞那肽
CAS号	141758-74-9
分子式（M.F.）	C184H282N50O60S
分子量（M.W.）	4186.57
储存条件	-20°C储存

敏感性	对湿度敏感
存贮条件	储存温度 -20°C
应用	Exendin-4能激活GLP-1受体，使该受体增加胰腺腺泡细胞(pancreatic acinar cells）的细胞内cAMP水平,但对VIP受体无效果。Exendin-4 has been used as incretin mimetics for the treatment in HepG2 cells to exclude the influence of auxiliary material. It has also been used as an r (GLP-1R) agonist to exclude interference from auxiliary material. Exendin-4 has been used for the treatment of ob/ob mouse model to determine the glucose and insulin concentrations and homeostasis model of assessment (HOMA), and for the determination of nuclear factor-κΒ (NF-κB) p65 level in macrophages treated with exendin-4.
产品介绍	Exendin-4是一种39个氨基酸的多肽Exendin-4 is an incretin mimetic peptide, which is composed of 39 amino acids. It is an analog of glucagon-like peptide 1 (GLP-1), and an insulinotropic agent, with a long half-life. It was originally isolated from the venom of Gila monster lizard called Heloderma suspectum.
生化机理	Exendin-4 mimics the activity of mammalian incretin hormone glucagon-like peptide 1 (GLP-1), and thus, functions in the control of glucose. This includes the secretion of insulin in a glucose dependent manner, negative regulation of high glucagon secretion, and increased duration of stomach emptying. In type 2 diabetes patients, this peptide can be administered subcutaneously for glycemic control, when metformin is unable to produce adequate results. It promotes the neogeneration and proliferation of β-cells, and thus aids in the regeneration of pancreas. It acts as a ligand to exendin receptor, and leads to an elevation of acinar cell cAMP levels.
别名	;H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

艾塞那肽

Exendin-4 （订货以英文为准）