| 沸点 | 253°C(lit.) |
| 熔点 | 15°C(lit.) |
| 别名 | ;['Perhydrofluorene (mixture of isomers)'] |
十二氢芴 (异构体混合物)
Dodecahydrofluorene (mixture of isomers) （订货以英文为准）
编号：D155176
CAS号：5744-03-6
分子式：C13H22
分子量：178.32
| 产品名称 | Dodecahydrofluorene (mixture of isomers) |
| 中文名称 | 十二氢芴 (异构体混合物) |
| CAS号 | 5744-03-6 |
| MDL编码 | D155176 |
| 分子式（M.F.） | C13H22 |
| 分子量（M.W.） | 178.32 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs02.jpg,https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg,https://www.aladdin-e.com/images/ghs/ghs09.jpg |
| 信号词 | Danger |
| 危害声明 | H225,H304,H315,H336,H361f,H373,H411 |
| 警示性声明 | P210,P261,P273,P281,P301+P310,P331 |
| 个人防护设备 | Eyeshields,Faceshields,full-face respirator (US),Gloves,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter |
| RTECS | MN9275000 |
| WGK德国 | 2 |
| 闪点（摄氏） | （闭杯）-17.2℃ |
| 风险声明 (欧洲) | R11;R38;R62;R65;R67;R48/20;R51/53 |
| 安全声明（欧洲） | S9;S16;S33;S36/37;S61;S62 |
| 危害码（欧洲） | F,Xn,N |
| 是否危化品 | 一般危化品 |
| UN代码 | 1208 |
技术规格
| Background: | Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3). |
| Applications: | WB |
| Name of antibody: | Mapt (phospho-Ser416) |
| Immunogen: | Synthetic peptide of Rat Mapt (phospho-Ser416) |
| Full name: | microtubule-associated protein tau (phospho-Ser416) |
| Synonyms： | pTau; Mtapt; RNPTAU |
| SwissProt: | P19332 |
| WB Predicted band size: | 48 kDa; 62 kDa; 78 kDa |
| WB Positive control: | Rat brain, Rat hippocampus and Mouse brain tissue |
| WB Recommended dilution: | 500-1000 |
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