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GSK343,细胞可穿透的histone H3-赖氨酸27（H3K27）甲基转移酶EZH2抑制剂

GSK343 （订货以英文为准）

编号：G126541
CAS号：1346704-33-3
分子式：C31H39N7O2
分子量：541.69
货号 品牌 包装 目录价 您的价格 库存 数量 购买
G126541-25mg 阿拉丁 25mg ¥1872.90
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G126541-100mg 阿拉丁 100mg ¥5458.90
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G126541-5mg 阿拉丁 5mg ¥406.90
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产品名称 GSK343
中文名称 GSK343,细胞可穿透的histone H3-赖氨酸27（H3K27）甲基转移酶EZH2抑制剂
CAS号 1346704-33-3
分子式（M.F.） C31H39N7O2
分子量（M.W.） 541.69
储存条件 2-8°C储存
溶解性DMSO: soluble15 mg/mL, clear
存贮条件储存温度2-8℃
应用An inhibitor of the histone lysine methyltransferase ENX-1.It is an epigenetic chemical probe available through a partnership between Sigma Life Science and the Structural Genomics Consortium (SGC).
产品介绍It is an epigenetic chemical probe available through a partnership between Sigma Life Science and the Structural Genomics Consortium (SGC).
生化机理It is a potent, specific inhibitor of the histone H3-lysine 27 (H3K27) methyltransferase EZH2. GSK343 inhibits EZH2 enzymatic activity with an IC50 of 4 nM. The compound displays 60 fold selectivity for EZH2 vs. EZH1, and 1000 fold or greater selectivity against other histone methyltransferases. The IC50 for inhibition of H3K27 methylation is < 200 nM in HCC1806 cells.
别名1-异丙基-N-[(6-甲基-2-氧代-4-丙基-1,2-二氢-3-吡啶基)甲基]-6-[2-(4-甲基-1-哌嗪基)-4-吡啶基]-1H-吲唑-4-甲酰胺;N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide
标识符号https://www.aladdin-e.com/images/ghs/ghs06.jpg
信号词Danger
危害声明H301
警示性声明P301 + P310
WGK德国3
搜索质检报告(COA)
搜索MSDS
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