| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | ONO-AE3-208(AE 3-208)是EP4拮抗剂，能抑制前列腺癌细胞侵袭，迁移和转移。 |
| 生化机理 | EP4 over-expressing LNCaP was established, and their cell invasiveness was compared with the control LNCaP (LNCaP/mock). The in vitro cell proliferation, invasion, and migration of these cells were examined under different concentrations of ONO-AE3-208. An in vivo bone metastatic mouse model was constructed by inoculating luciferase expressing PC3 cells into left ventricle of nude mice. Their bone metastasis was observed by bioluminescent imaging with or without ONO-AE3-208 administration. The EP4 mRNA expression levels were higher in PC3 than in LNCaP, and EP4 over-expression of LNCaP cells enhanced their cell invasiveness.Arachidonic acid caused dose-dependent dilation of the attached Af-Art (from 8.6 ± 1.2 to 15.3 ± 0.7 μm; P<0.001; n=6), and this effect was blocked by ONO-AE3-208 (10(-7) mol/L). |
| 别名 | AE 3-208;ONO AE3 208； 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸;AE 3-208;ONO AE3 208；4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid |
ONO-AE3-208,性EP4拮抗剂
ONO-AE3-208 （订货以英文为准）
编号：O125509
CAS号：402473-54-5
分子式：C24H21FN2O3
分子量：404.43
| 产品名称 | ONO-AE3-208 |
| 中文名称 | ONO-AE3-208,性EP4拮抗剂 |
| CAS号 | 402473-54-5 |
| 分子式（M.F.） | C24H21FN2O3 |
| 分子量（M.W.） | 404.43 |
| 储存条件 | -20°C储存 |
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