| 沸点 | 621.04 °C at 760 mmHg |
| 折光率 | 1.63 |
| 溶解性 | DMSO 25 mg/mL Ethanol 75 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.2800 |
| 应用 | A potent and selective monopolar spindle 1 (Mps1) kinase inhibitor |
| 产品介绍 | AZ3146是单极纺锤体1（Mps1）激酶抑制剂，IC50为35 nM，对FAK，JNK1，JNK2和Kit的抑制性较弱。 |
| 备注 | AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit. |
| 生化机理 | AZ3146 is a potent and specific inhibitor of monopolar spindle 1 kinase (Mps1; IC50 = 35 nM), an important regulator of Spindle Assembly Checkpoint (SAC). AZ3146 treated HeLa cells override SAC, and quickly enter mitosis, with a reduced mitosis completion time of 32 minutes. 50% of treated cells entered anaphase without complete chromosomal alignment. |
| 别名 | 9-环戊基-7,9-二氢-2-((2-甲氧基-4-((1-甲基-4-哌啶基)氧基)苯基)氨基)-7-甲基-8H-嘌呤-8-酮;;AZ 3146;AZ-3146; 9-cyclopentyl-7,9-dihydro-2-((2-methoxy-4-((1-methyl-4-piperidinyl)oxy)phenyl)amino)-7-methyl-8h-purin-8-one;9-cyclopentyl-2-[2-methoxy-4-(1-methylpiperidin-4-yl)oxyanilino]-7-methylpurin-8-one |
AZ 3146,强力Mps1激酶抑制剂
AZ 3146 （订货以英文为准）
编号：A127268
CAS号：1124329-14-1
分子式：C24H32N6O3
分子量：452.55
| 产品名称 | AZ 3146 |
| 中文名称 | AZ 3146,强力Mps1激酶抑制剂 |
| CAS号 | 1124329-14-1 |
| 分子式（M.F.） | C24H32N6O3 |
| 分子量（M.W.） | 452.55 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H315,H319,H334,H335 |
| 警示性声明 | P261,P305+P351+P338,P342+P311 |
| 个人防护设备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| RTECS | BV8053000 |
| WGK德国 | 3 |
| 风险声明 (欧洲) | R36/37/38,R43 |
| 安全声明（欧洲） | S22,S24/25 |
| 危害码（欧洲） | Xi |
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