| 折光率 | 1.64 |
| 溶解性 | Soluble in DMSO (100 mg/ml (~115mM) at 25 °C), water (<1 mg/ml (< 1mM) at 25 °C), and ethanol (<1 mg/ml (< 1mM) at 25 °C). |
| 存贮条件 | 储存温度-20°C |
| 应用 | A Bcl-2-selective inhibitor with Ki of <0.01 nM |
| 产品介绍 | ABT-199 (GDC-0199)是高效的Bcl-2选择性抑制剂，Ki为0.01 nM，比对Bcl-xL和Bcl-w的抑制性高4800倍以上，对Mcl-1无活性。 |
| 备注 | ABT-199 (GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Phase 2. |
| 生化机理 | ABT-199 is a potent and selective inhibitor of B-cell lymphoma-2 (BCL-2) family proteins, currently in clinical trials. ABT-199 inhibits the growth of BCL-2-dependent tumors in vivo and spares human platelets. A single dose of ABT-199 in three patients with refractory chronic lymphocytic leukemia resulted in tumor lysis within 24 h. These data indicate that selective pharmacological inhibition of BCL-2 shows promise for the treatment of BCL-2-dependent hematological cancers. |
| 别名 | GDC-0199;GDC-0199;ABT199;ABT 199;GDC0199;GDC 0199;Venetoclax ; abt 199;4-(4-((2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-n-((3-nitro-4-(((tetrahydro-2h-pyran-4-yl)methyl)amino)phenyl)sulfonyl)-2-(1h-pyrrolo(2,3-b)pyridin-5-yloxy)-benzamide |
ABT-199 (GDC-0199),Bcl-2抑制剂
ABT-199 (GDC-0199) （订货以英文为准）
编号：A124869
CAS号：1257044-40-8
分子式：C45H50CLN7O7S
分子量：868.44
| 产品名称 | ABT-199 (GDC-0199) |
| 中文名称 | ABT-199 (GDC-0199),Bcl-2抑制剂 |
| CAS号 | 1257044-40-8 |
| 分子式（M.F.） | C45H50CLN7O7S |
| 分子量（M.W.） | 868.44 |
| 储存条件 | 避光;-20°C储存 |
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