溶解性 | Soluble in water (<1 mg/ml at 25 °C), DMSO (92 mg/ml at 25 °C), methanol (warmed), and ethanol (<1 mg/ml at 25 °C). |
存贮条件 | 储存温度-20°C |
应用 | An inhibitor of thymidylate synthase and DHFR. |
产品介绍 | Raltitrexed是一种胸苷酸合成酶抑制剂,抑制L1210细胞生长,IC50为9 nM。 |
备注 | Raltitrexed is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth. |
生化机理 | Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. Raltitrexed is an inhibitor of DHFR. |
别名 | 雷替曲塞;Tomudex; TDX; ZD1694; D1694; ICI-D1694;(S)-2-[(1-{5-[Methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-thiophen-2-yl}-methanoyl)-amino]-pentanedioic acid |
雷替曲塞
Raltitrexed (订货以英文为准)
编号:R129835
CAS号:112887-68-0
分子式:C21H22N4O6S
分子量:458.49
产品名称 | Raltitrexed |
中文名称 | 雷替曲塞 |
CAS号 | 112887-68-0 |
分子式(M.F.) | C21H22N4O6S |
分子量(M.W.) | 458.49 |
储存条件 | -20°C储存 |
WGK德国 | 3 |
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