| 溶解性 | Soluble in methanol (sparingly), water (<1 mg/ml at 25 °C), DMF (~16 mg/ml), ethanol (28 mg/ml at 25 °C), and DMSO (~2 mg/ml). |
| 存贮条件 | 储存温度-20°C |
| 应用 | A steroidal inhibitor of CYP17A1 in androgen biosynthesis |
| 产品介绍 | Abiraterone Acetate是Abiraterone的醋酸盐形式，是一种甾体类细胞色素CYP17抑制剂，IC50为72 nM。 |
| 备注 | Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM. |
| 生化机理 | Abiraterone acetate has been seen to be a novel steroidal inhibitor of CYP17A1(C17,20 lyase), a cytoochrome P450 complex, a rate-limiting enzyme in androgen biosynthesis resulting in inhibtion of testosterone production in both the adrenals and the testes. It has been observed to decrease the DHEA, androstenedione and testosterone. The compound has been shown to be approximately 21-24 times more potent than ketoconazole and liarozole in CYP17A1 lyase inhibition. In medicine, Abiraterone is used for treating prostate cancer. |
| 别名 | 乙酸阿比特龙酯;CB 7630, CB-7630;(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate |
乙酸阿比特龙酯
Abiraterone Acetate （订货以英文为准）
编号：A129731
CAS号：154229-18-2
分子式：C26H33NO2
分子量：391.55
| 产品名称 | Abiraterone Acetate |
| 中文名称 | 乙酸阿比特龙酯 |
| CAS号 | 154229-18-2 |
| 分子式（M.F.） | C26H33NO2 |
| 分子量（M.W.） | 391.55 |
| 储存条件 | -20°C储存 |
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