熔点 | 224.0 to 228.0℃ |
溶解性 | Soluble in DMSO (5 mg/ml), ethanol, methanol, and Chloroform.Insolule in water. |
存贮条件 | 储存温度-20°C |
应用 | An adenylate cyclase activator and MAP kinase inhibitor |
产品介绍 | Forskolin是一种普遍存在的真核细胞腺苷酸环化酶(AC)激活剂,在细胞生理学研究中,常用来提高cAMP水平。 |
备注 | Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC), commonly used to raise levels of cAMP in the study and research of cell physiology. |
生化机理 | Forskolin is a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo producing positive inotropic, platelet anti-aggregatory and anti-hypertensive effects. Has also been shown to exhibit smooth muscle relaxant activity, decrease in intraocular pressure and the promotion of hormonal release from the pituitary glands. Inhibits MAP kinase, induces phosphorylation of CREB, connexin 43, Bad, ATF-1 and PKB. Forskolin is an inhibitor of AChR. |
别名 | 佛司可林;毛喉素;佛司可林;7β-乙酰氧基-8,13--环氧-1α,6β,9α-三羟基labd-14-烯-11-酮;洋紫苏醇;考福新;;Coleonol;Colforsin;Boforsin; 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one |
佛司可林
Forskolin (订货以英文为准)
编号:F127328
CAS号:66575-29-9
分子式:C22H34O7
分子量:410.50
产品名称 | Forskolin |
中文名称 | 佛司可林 |
CAS号 | 66575-29-9 |
分子式(M.F.) | C22H34O7 |
分子量(M.W.) | 410.50 |
储存条件 | -20°C储存 |
标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
信号词 | Warning |
危害声明 | H302 |
个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
RTECS | UB8390000 |
WGK德国 | 3 |
风险声明 (欧洲) | R22 |
安全声明(欧洲) | S36;S60 |
危害码(欧洲) | Xn |
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