| 溶解性 | Soluble in water (1 mg/ml at 25 °C), DMSO (79 mg/ml at 25 °C), ethanol (33 mg/ml at 25 °C), and methanol. |
| 存贮条件 | 储存温度-20°C |
| 应用 | An allosteric activator of CaSR |
| 产品介绍 | Cinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR (calcium sensing receptors). Studies show that Cinacalcet Hydrochloride affects cell proliferation in CHO cells transfected with CaSRs. In addition, it is known that Cinacalcet Hydrochloride inhibits the secretion of the parathyroid hormone (PTH). These studies suggest that Cinacalcet Hydrochloride in instrumental in increasing the cytoplasmic concentration of Ca2+. Furthermore, Cinacalcet Hydrochloride is an analog of NPS R-568 which contains a much better metabolic profile. |
| 备注 | AMG-073 represents a new class of compounds for the treatment of hyperparathyroidism. |
| 生化机理 | AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism. |
| 别名 | Mimpara, Sensipar;(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride;盐酸西那卡塞;盐酸甲状旁腺激素;N-((1R)-1-(1-萘基)乙基)-3-(3-(三氟甲基)苯基)丙-1-胺盐酸盐 |
盐酸西那卡塞
Cinacalcet HCl （订货以英文为准）
编号：C129866
CAS号：364782-34-3
分子式：C22H22F3N.HCL
分子量：393.87
| 产品名称 | Cinacalcet HCl |
| 中文名称 | 盐酸西那卡塞 |
| CAS号 | 364782-34-3 |
| 分子式（M.F.） | C22H22F3N.HCL |
| 分子量（M.W.） | 393.87 |
| 储存条件 | -20°C储存 |
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