PD0325901,MEK1 / 2的抑制剂

PD0325901 (订货以英文为准)

编号:P125494
CAS号:391210-10-9
分子式:C16H14F3IN2O4
分子量:482.19
货号 品牌 包装 目录价 您的价格 库存 数量 购买
P125494-100mg 阿拉丁 100mg ¥2622.90
P125494-25mg 阿拉丁 25mg ¥872.90
P125494-5mg 阿拉丁 5mg ¥458.90
产品名称 PD0325901
中文名称 PD0325901,MEK1 / 2的抑制剂
CAS号 391210-10-9
分子式(M.F.) C16H14F3IN2O4
分子量(M.W.) 482.19
储存条件 -20°C储存
溶解性Soluble in DMF (~25 mg/ml), DMSO (96 mg/ml at 25 °C), ethanol (40 mg/ml at 25 °C), and methanol. Insoluble in water (25 oC).
存贮条件储存温度-20°C
应用An inhibitor of MEK and suppressor of ERK phosphorylation
产品介绍PD0325901是一种选择性的,ATP非竞争性的MEK抑制剂,IC50为0.33 nM,对ERK1和ERK2磷酸化抑制作用比CI-1040强500倍左右
备注PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 1/2.
生化机理PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK1/2 in murine colon 26 tumors with an IC50 value of 0.33 nM. As a result of this inhibition, PD 0325901 modulates regulators of cell growth and apoptosis at the protein level. Studies on M14 models indicate that PD 0325901 inhibits the phosphorylation of ERK and its downstream target ribosomal S6 kinase in a dose-dependent manner. This inhibition was rapid with complete, occurring at 15 minutes and lasting at least 72 hours. When combined with GSK-3 Inhibitor XVI (CHIR99021) this inhibitor prevents cell differentiation and sustains self renewal of murine embryonic stem cells for at least eight passages
别名N-[(2R)-2,3-二羟基丙氧基]-3,4-二氟-2-[(2-氟-4-碘苯)氨基]苯甲酰胺;PD 0325901; PD-0325901;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
标识符号https://www.aladdin-e.com/images/ghs/ghs06.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg,https://www.aladdin-e.com/images/ghs/ghs09.jpg
信号词Danger
危害声明H301-H360F-H373-H410
警示性声明P201-P273-P301 + P310-P308 + P313-P501
个人防护设备Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSTK7912300
WGK德国3
搜索质检报告(COA)
搜索MSDS
相关产品
CAS号:7704-98-5
¥ 419.00 T819979-100g
CAS号:7758-02-3
¥ 223.00 P816703-25g
CAS号:288-32-4
¥ 60.00 I811843-25g
CAS号:7791-20-0
¥ 899.00 N814991-5g
CAS号:71-41-0
¥ 115.00 P815993-500ml
CAS号:108-46-3
¥ 225.00 R817303-100g
CAS号:1499-10-1
¥ 556.00 D807000-250mg
CAS号:98-88-4
¥ 258.00 B802234-500g
CAS号:9002-92-0
¥ 520.00 767315-5g