| 熔点 | 278°C |
| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in DMSO (5 mg/mL,warm to 40°C), water (<1 mg/mL) at 25 °C, and ethanol (<1 mg/mL) at 25 °C |
| 存贮条件 | 储存温度2-8℃ |
| 应用 | An antiangiogenic and antiinflammatory agonist of TRPV1. |
| 产品介绍 | Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin .Evodiamine induction of 45Ca2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine .Evodiamine is described to inhibit prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects. |
| 生化机理 | The interferon-γ priming signal regulating the transcriptional activation of the iNOS gene is blocked by Evodiamine, suppressing iNOS protein synthesis but not affecting iNOS function. Evodiamine also demonstrates antiangiogenesis through inhibition of vascular endothelial growth factor gene expression and inhibition of the ERK 1 (p44)/ERK 2 (p42) mitogen-activated protein kinase that correlated to endothelial cell angiogenesis. Promotion of apoptosis in human leukemic U937 cells is described with Evodiamine. |
| 别名 | 吴茱萸胺; |
(±)-吴茱萸碱
(±)-Evodiamine （订货以英文为准）
编号：E140884
CAS号：518-18-3
分子式：C19H17N3O
分子量：303.36
| 产品名称 | (±)-Evodiamine |
| 中文名称 | (±)-吴茱萸碱 |
| CAS号 | 518-18-3 |
| 分子式（M.F.） | C19H17N3O |
| 分子量（M.W.） | 303.36 |
| 储存条件 | 2-8°C储存 |
| 个人防护设备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
| RTECS | FW6420000 |
| WGK德国 | 3 |
| 安全声明（欧洲） | S22;S24/25; |
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