溶解性 | 25°C: DMSO2mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL |
存贮条件 | 储存温度-20°C |
应用 | A novel inhibitor of Met (IC50 = 0.13 nM) |
产品介绍 | INCB28060是高活性c-MET口服活性抑制剂,IC50为0.13 nM。 |
备注 | INCB28060 is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM, inactive against RONβ, as well as EGFR and HER-3. Phase 1. |
生化机理 | INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. INCB28060 inhibits human c-MET phosphorylation and c-MET-mediated signaling in cancer cells. INCB28060 inhibits c-MET-dependent cell proliferation and survival, and prevents anchorage-independent cancer cell growth and cell migration. |
别名 | INCB-28060; INC-280;2-氟-N-甲基-4-(7-((喹啉-6-基)甲基)咪唑并(1,2-b)-(1,2,4)三嗪-2-基)苯甲酰胺;;Capmatinib; INCB-28060; INC-280;2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2- yl)benzamide |
卡马替尼 (INCB28060)
Capmatinib (INCB28060) (订货以英文为准)
编号:I127200
CAS号:1029712-80-8
分子式:C23H17FN6O
分子量:412.42
产品名称 | Capmatinib (INCB28060) |
中文名称 | 卡马替尼 (INCB28060) |
CAS号 | 1029712-80-8 |
分子式(M.F.) | C23H17FN6O |
分子量(M.W.) | 412.42 |
储存条件 | -20°C储存 |
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