| 溶解性 | DMSO 62 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | U-104是碳酸酐酶(Carbonic anhydrase)CA IX和CA XII高效抑制剂，Ki值分别为45.1nM和4.5nM。 |
| 备注 | U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II. |
| 生化机理 | U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX. |
| 别名 | NSC 213841;U 104;4-[[[(4-氟苯基)氨基]羰基]氨基]苯磺酰胺;NSC-213841;MST-104;4-[[[(4-Fluorophenyl)amino]carbonyl]amino]benzenesulfonamide |
U-104,碳酸酐酶（CA）IX和XII抑制剂
U-104 （订货以英文为准）
编号：U129821
CAS号：178606-66-1
分子式：C13H12FN3O3S
分子量：309.32
| 产品名称 | U-104 |
| 中文名称 | U-104,碳酸酐酶（CA）IX和XII抑制剂 |
| CAS号 | 178606-66-1 |
| 分子式（M.F.） | C13H12FN3O3S |
| 分子量（M.W.） | 309.32 |
| 储存条件 | -20°C储存 |
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