| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | 360A是G-四联体结构高亲和性抑制剂。 |
| 生化机理 | Description:IC50 Value: N/A360A is a 2,6-pyridine-dicarboxamide derivative displaying strong affinity and selectivity for G-quadruplex structures and selective telomerase inhibition in vitro assays. 360A is a G-quadruplex ligand, which can influence the consequence of G-quadruplex formation and/or stabilization.in vitro: We found a S-phase accumulation in ATM-proficient, but not in ATM-deficient EBV-lymphocytes treated with 360A before induction of cell death. However, ATM status did not modify cell cycle distribution in 360A-treated SV40-fibroblasts and HeLa cells compared to DMSO treated controls [1]. DNA-PKcs-dependent NHEJ was responsible for sister telomere fusions as a direct consequence of G-quadruplex formation and/or stabilization induced by 360A on parental telomere G strands. NHEJ and HR activation at telomeres altered mitotic progression in treated cells [2]. This compound was shown to display a potent affinity and selectivity for telomeri |
| 别名 | 360 A；3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉鎓];360 A；3,3'-[2,6-Pyridinediylbis(carbonylimino)]bis[1-methylquinolinium] |
360A,一种 G-四联体 (G-quadruplex) 的稳定剂
360A （订货以英文为准）
编号：A127374
CAS号：794458-56-3
分子式：C27H23N5O2+2.2[I-]
分子量：703.31
| 产品名称 | 360A |
| 中文名称 | 360A,一种 G-四联体 (G-quadruplex) 的稳定剂 |
| CAS号 | 794458-56-3 |
| 分子式（M.F.） | C27H23N5O2+2.2[I-] |
| 分子量（M.W.） | 703.31 |
| 储存条件 | -20°C储存 |
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