| 溶解性 | Soluble in water (>89 mg/ml), DMSO (>89 mg/ml), ethanol (>24 mg/ml), DMF (~3 mg/ml), and PBS (pH 7.2) (~10 mg/ml). |
| 存贮条件 | 储存温度-20°C |
| 应用 | An inhibitor of survivin expression and apoptosis inducer. |
| 产品介绍 | YM155 (Sepantronium Bromide)是一种有效的survivin抑制药，通过抑制Survivin启动子活性而发挥作用，在HeLa-SURP-luc 和 CHO-SV40-luc细胞中IC50为0.54 nM；对SV40启动子活性抑制作用不显著，能够轻微抑制Survivin与XIAP相互作用。 |
| 备注 | YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. Phase 1/2 |
| 生化机理 | YM155 is a small molecule inhibitor of survivin expression that acts by inhibiting the survivin gene promoter transcription. Shown to induce apoptosis and inhibit tumor growth. |
| 别名 | YM 155; YM-155;4,9-二氢-1-(2-甲氧基乙基)-2-甲基-4,9-二氧代-3-(2-吡嗪甲基)-1H-萘并[2,3-d]咪唑鎓溴化物;YM155; Sepantronium bromide;YM 155;YM-155;1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide;4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide |
YM155 (Sepantronium Bromide),新型小分子survivin 抑制剂
YM155 (Sepantronium Bromide) （订货以英文为准）
编号：Y126171
CAS号：781661-94-7
分子式：C20H19BRN4O3
分子量：443.29
| 产品名称 | YM155 (Sepantronium Bromide) |
| 中文名称 | YM155 (Sepantronium Bromide),新型小分子survivin 抑制剂 |
| CAS号 | 781661-94-7 |
| 分子式（M.F.） | C20H19BRN4O3 |
| 分子量（M.W.） | 443.29 |
| 储存条件 | -20°C储存 |
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