| 沸点 | 259°C |
| 密度 | 0.9890 |
| 别名 | 2,2'-二甲基联苯;2,2'-Dimethylbiphenyl; 2,2'-Bitolyl |
2,2'-二甲基联苯
2,2'-Dimethylbiphenyl （订货以英文为准）
编号：D155043
CAS号：605-39-0
分子式：C14H14
分子量：182.27
| 产品名称 | 2,2'-Dimethylbiphenyl |
| 中文名称 | 2,2'-二甲基联苯 |
| CAS号 | 605-39-0 |
| MDL编码 | MFCD00048075 |
| 分子式（M.F.） | C14H14 |
| 分子量（M.W.） | 182.27 |
| Reaxys-RN | 1852621 |
| 信号词 | Warning |
| 危害声明 | H302-H413 |
| 个人防护设备 | dust mask type N95 (US)， Eyeshields， Gloves |
| WGK德国 | 3 |
技术规格
| Background: | p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes |
| Applications: | WB, IF |
| Name of antibody: | TP53 (Phospho-Ser46) |
| Immunogen: | Synthetic peptide of human TP53 (Phospho-Ser46) |
| Full name: | tumor protein p53 (Phospho-Ser46) |
| Synonyms： | P53; BCC7; LFS1; TRP53 |
| SwissProt: | P04637 |
| WB Predicted band size: | 44 kDa |
| WB Positive control: | MCF cells untreated or treated with Anisomycin |
| WB Recommended dilution: | 500-1000 |
| IF Positive control: | Hela cells |
| IF Recommended dilution | 100-200 |
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