| 溶解性 | DMSO 100 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | PHA-680632是Aurora A，Aurora B和Aurora C抑制剂，IC50分别为27 nM，135 nM和120 nM。 |
| 生化机理 | HA-680632 (15-60 mg/kg) inhibits tumor growth in mice xenografts models of HL60, A2780, and HCT116 cells, by reducing tumor cell proliferation and increasing apoptosis. PHA-680632 (45 mg/kg) suppresses growth of activated ras-driven mammary tumors in mouse mammary tumor virus v-Ha-ras transgenic mice and results in complete tumor stabilization and partial regression. |
| 别名 | PHA680632;PHA 680632; N-(2,6-二乙基苯基)-4,6-二氢-3-((4-(4-甲基-1-哌嗪基)苯甲酰基)氨基)吡咯并(3,4-c)吡唑-5(1H)-甲酰胺;;PHA680632;PHA 680632;n-(2,6-diethylphenyl)-4,6-dihydro-3-((4-(4-methyl-1-piperazinyl)benzoyl)amino)pyrrolo(3,4-c)pyrazole-5(1h)-carboxamide |
PHA-680632
PHA-680632 （订货以英文为准）
编号：P125501
CAS号：398493-79-3
分子式：C28H35N7O2
分子量：501.64
| 产品名称 | PHA-680632 |
| 中文名称 | PHA-680632 |
| CAS号 | 398493-79-3 |
| 分子式（M.F.） | C28H35N7O2 |
| 分子量（M.W.） | 501.64 |
| 储存条件 | -20°C储存 |
| WGK德国 | 3 |
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