LDN-193189,BMP I 型受体抑制剂

LDN-193189 (订货以英文为准)

编号:L127229
CAS号:1062368-24-4
分子式:C25H22N6
分子量:479.40
货号 品牌 包装 目录价 您的价格 库存 数量 购买
L127229-5mg 阿拉丁 5mg ¥924.90
L127229-25mg 阿拉丁 25mg ¥3089.90
产品名称 LDN-193189
中文名称 LDN-193189,BMP I 型受体抑制剂
CAS号 1062368-24-4
分子式(M.F.) C25H22N6
分子量(M.W.) 479.40
储存条件 -20°C储存
溶解性DMSO 0.01 mg/mL (<1 mM); Water 0.01 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM)
存贮条件储存温度-20°C
产品介绍LDN-193189是一种选择性的BMP信号通路抑制剂,抑制BMP I型受体ALK2和ALK3的转录活性,IC50分别为5 nM和30 nM,作用于BMP比作用于TGF-β选择性高200倍。
备注LDN193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
生化机理LDN193189 is a highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; LDN193189 is useful tool in stem cell biology. LDN193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors.
别名4-[6-(4-(哌嗪-1-基)苯基]吡唑并[1,5-a]嘧啶-3-基)喹啉;LDN 193189; LDN-193189; DM-3189; DM 3189;4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
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