| 溶解性 | DMSO 9 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A PI3K and FRAP inhibitor with some action against Akt |
| 产品介绍 | TG100-115是PI3K γ和δ抑制剂，IC50分别为83和235 nM。 |
| 备注 | TG100115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2. |
| 生化机理 | TG100-115 inhibits PI 3-kinase p110 γ and PI 3-kinase p110 δ (PI3Kγ and -δ), with IC50 of 83 and 235 nM, respectively. TG100-115 is not active for PI3Kα and -β, with IC50 of 1.2 and 1.3 mM. TG100-115 (10 μM) interrupts other VEGF signaling pathways, such as those that culminate in VE-cadherin phosphorylation. In HUVECs, TG100-115 (10 μM) inhibits the VEGF-induced increase of total level of VE-cadherin. TG100-115 inhibits VEGF mediated phosphorylation of mTOR, also known as FRAP, and p70S6 kinase, both of which are downstream of PI3K. TG100-115 (125 nM to 10 μM) also inhibits FGF-stimulated phosphorylation of Akt. |
| 别名 | TG100115;TG100 115;3,3'-(2,4-二氨基-6,7-蝶啶二基)二苯酚;TG100115;TG100 115;3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol;6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine |
TG100-115,PI3Kγ/δ抑制剂
TG100-115 （订货以英文为准）
编号：T127783
CAS号：677297-51-7
分子式：C18H14N6O2
分子量：346.35
| 产品名称 | TG100-115 |
| 中文名称 | TG100-115,PI3Kγ/δ抑制剂 |
| CAS号 | 677297-51-7 |
| 分子式（M.F.） | C18H14N6O2 |
| 分子量（M.W.） | 346.35 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Warning |
| 危害声明 | H315-H319-H335 |
| 警示性声明 | P261-P305 + P351 + P338 |
| 个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
| WGK德国 | 3 |
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