| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | PF-04457845是FAAH选择性抑制剂，IC50为7.2 nM，具有镇痛和抗炎活性。 |
| 生化机理 | PF-04457845 is a potent and exquisitely selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 7.2nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen. It has been well tolerated in human trials even at high dose ranges with no evidence for cognitive dysfunction, and has completed Phase II clinical trials for the treatment of osteoarthritis. From Wikipedia. |
| 别名 | PF 04457845; PF04457845;N-哒嗪-3-基-4-(3-{[5-(三氟甲基)吡啶-2-基]醚}苯亚甲基丙酮)哌啶-1-羧酰胺;PF 04457845; PF04457845;N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide |
PF-04457845,不可逆FAAH抑制剂
PF-04457845 （订货以英文为准）
编号：P127989
CAS号：1020315-31-4
分子式：C23H20F3N5O2
分子量：455.43
| 产品名称 | PF-04457845 |
| 中文名称 | PF-04457845,不可逆FAAH抑制剂 |
| CAS号 | 1020315-31-4 |
| 分子式（M.F.） | C23H20F3N5O2 |
| 分子量（M.W.） | 455.43 |
| 储存条件 | -20°C储存 |
| Reaxys-RN | 7655141 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Warning |
| 危害声明 | H315-H319-H413 |
| 警示性声明 | P305 + P351 + P338 |
| RTECS | XJ9007750 |
| WGK德国 | 3 |
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