| 溶解性 | DMSO 42 mg/mL Water <1 mg/mL Ethanol 4 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | CP 673451是PDGFRα和β选择性抑制剂，IC50分别为10 nM和1 nM，比对其它血管生成受体的抑制性强450倍，有抗血管生成和抗肿瘤活性。 |
| 备注 | CP 673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity. |
| 生化机理 | CP-673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM. A dose of 33 mg/kg was adequate to provide >50% inhibition of receptor for 4 hours corresponding to an EC50 of 120 ng/mL in plasma at Cmax. In a sponge angiogenesis model, CP-673451 inhibited 70% of PDGF-BB-stimulated angiogenesis at a dose of 3 mg/kg (q.d. × 5, p.o., corresponding to 5.5 ng/mL at Cmax). CP-673451 did not inhibit vascular endothelial growth factor- or basic fibroblast growth factor-induced angiogenesis at concentrations which inhibited tumor growth. |
| 别名 | CP 673451;CP673451； 1-(2-(5-(2-甲氧基乙氧基)苯并咪唑-1-基)喹啉-8-基)哌啶-4-基胺;;CP 673451; CP673451; 1-(2-(5-(2-methoxyethoxy)benzimidazol-1-yl)quinolin-8-yl)piperidin-4-ylamine |
CP-673451,PDGFR抑制剂
CP-673451 （订货以英文为准）
编号：C125124
CAS号：343787-29-1
分子式：C24H27N5O2
分子量：417.50
| 产品名称 | CP-673451 |
| 中文名称 | CP-673451,PDGFR抑制剂 |
| CAS号 | 343787-29-1 |
| 分子式（M.F.） | C24H27N5O2 |
| 分子量（M.W.） | 417.50 |
| 储存条件 | -20°C储存 |
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