| 溶解性 | DMSO 61 mg/mL Water <1 mg/mL Ethanol 21 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A novel allosteric modulator of mGluR-5 receptors |
| 产品介绍 | VU0357121是新型的mGlu5R正向变构调节剂，EC50为33 nM。 |
| 生化机理 | VU0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax. Its site of action is distinct from the classical mGlu5 negative allosteric modulator (NAM) MPEP allosteric site or the site of a recetly discovered PAM, CPPHA. However, VU0357121shares a functional interaction with the MPEP site. VU0357121 is highly selective for activation of mGlu5 and is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
| 别名 | 4-丁氧基-N-(2,4-二氟苯基)苯甲酰胺;VU0357121; VU-0357121; 4-Butoxy-N-(2,4-difluorophenyl)-benzamide |
VU 0357121,mGlu5受体的正变构调节剂
VU 0357121 （订货以英文为准）
编号：V129515
CAS号：433967-28-3
分子式：C17H17F2NO2
分子量：305.32
| 产品名称 | VU 0357121 |
| 中文名称 | VU 0357121,mGlu5受体的正变构调节剂 |
| CAS号 | 433967-28-3 |
| 分子式（M.F.） | C17H17F2NO2 |
| 分子量（M.W.） | 305.32 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Warning |
| 危害声明 | H302 |
| 个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
| RTECS | XJ9089100 |
| WGK德国 | 3 |
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