| 溶解性 | DMSO : ≥ 100 mg/mL (247.25 mM) H2O : < 0.1 mg/mL (insoluble) |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Ipragliflozin (ASP1941) is a highly potent and selective SGLT2 inhibitor with IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6. IC50 value: 2.8 nM Target: SGLT2 in vitro: Ipragliflozin potently and selectively inhibited human, rat, and mouse SGLT2 at nanomolar ranges and exhibited stability against intestinal glucosidases. in vivo: Ipragliflozin showed good pharmacokinetic properties following oral dosing, and dose-dependently increased urinary glucose excretion, which lasted for over 12 h in normal mice. Oral administration of ipragliflozin increased urinary glucose excretion in a dose-dependent manner, an effect which was significant at doses of 0.3 mg/kg or higher and lasted over 12 h. Single administration of ipragliflozin dose-dependently increased urinary glucose excretion, reduced blood glucose and plasma insulin levels, and improved glucose intolerance . |
| 别名 | (1S)-1,5-脱水-1-C-[3-[(1-苯并噻吩-2-基)甲基]-4-氟苯基]-D-葡糖醇;(1S)-1,5-Anhydro-1-C-[3-[(1-benzothiophen-2-yl)methyl]-4-fluorophenyl]-D-glucitol |
Ipragliflozin,抑制剂
Ipragliflozin （订货以英文为准）
编号：I177384
CAS号：761423-87-4
分子式：C21H21O5FS
分子量：404.45
| 产品名称 | Ipragliflozin |
| 中文名称 | Ipragliflozin,抑制剂 |
| CAS号 | 761423-87-4 |
| 分子式（M.F.） | C21H21O5FS |
| 分子量（M.W.） | 404.45 |
| 储存条件 | -20°C储存 |
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