概述
Recombinant Human Neutrophil gelatinase-associated lipocalin is produced by our Mammalian expression system and the target gene encoding Gln21-Gly198 is expressed with a 6His tag at the C-terminus.
使用说明
This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
技术规格
| Tag | C-6His |
| 种属 | Human |
| 表达系统 | Human cells |
| Accession# | P80188 |
| Source | Human Cells |
| Formulation_Description | Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4. |
| Storage | Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles. |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test. |
| Background | LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. LCN2 binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. LCN2 is involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. LCN2 is involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. |
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