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Ki16425,LPA1和LPA3受体拮抗剂

Ki16425 （订货以英文为准）

编号：K126742
CAS号：355025-24-0
分子式：C23H23CLN2O5S
分子量：474.96
货号 品牌 包装 目录价 您的价格 库存 数量 购买
K126742-5mg 阿拉丁 5mg ¥593.90
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K126742-1mg 阿拉丁 1mg ¥195.90
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K126742-100mg 阿拉丁 100mg ¥949.90
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K126742-25mg 阿拉丁 25mg ¥791.90
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产品名称 Ki16425
中文名称 Ki16425,LPA1和LPA3受体拮抗剂
CAS号 355025-24-0
分子式（M.F.） C23H23CLN2O5S
分子量（M.W.） 474.96
储存条件 -20°C储存
沸点623.7° C at 760 mmHg
熔点59.5-60.5° C
折光率1.63
溶解性DMSO 95 mg/mL Water <1 mg/mL Ethanol 95 mg/mL
存贮条件储存温度-20°C
密度1.3500
应用A competitive inhibitor of EDG-2, EDG-4, and EDG-7.
产品介绍Ki16425是竞争性的可逆的LPA拮抗剂，对LPA1，LPA2和LPA3的Ki分别为0.34 μM，6.5 μM和0.93 μM，而对LPA4，LPA5和LPA6无活性。
生化机理Kil6425 preferentially inhibits LPA1- and LPA3-mediated responses but has only a moderate effect on LPA2. Ki16425 inhibits the LPA-induced Ca(2+) response in THP-1 cells, 3T3 fibroblasts, and A431 cells, but had only a marginal effect in PC-12 cells and HL-60 cells, which means that Ki16425 seems to be a useful tool for evaluating the involvement of specific LPA receptors in the short-term response to LPA. Ki16425 inhibits long-term DNA synthesis and cell migration as induced by LPA in Swiss 3T3 fibroblasts . Ki16425 reduces the LPA-induced activation of p42/p44 mitogen activated protein kinase (MAPK), while acting as a weak stimulator of p42/p44 MAPK on its own, properties typical of a protean agonist. Ki16425 also significantly reduces the NGF-induced stimulation of p42/p44 MAPK and inhibited NGF-stimulated neurite outgrowth in PC-12 cells.
别名Ki-16425; Ki 16425; 3-[[[4-[4-[[[1-(2-氯苯基)乙氧基]羰基]氨基]-3-甲基-5-异恶唑基]苯基]甲基]硫基]丙酸;Ki-16425; Ki 16425; 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]-propanoic acid
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