| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Clemizole是H1受体拮抗剂，还能抑制NS4B的RNA结合及HCV的复制。 |
| 生化机理 | Description:IC50 Value: 8mM (NS4B) [1]Clemizole is an H1 histamine receptor antagonist. Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.in vitro: Although significant, clemizole's antiviral effect is moderate (50% effective concentration of 8 microM against an HCV genotype 2a clone). Combinations of clemizole with either interferon, ribavirin, or the nucleoside (NM283) and nonnucleoside (HCV796) HCV polymerase inhibitors were additive [1]. The differences in the rodent and human pathways for clemizole metabolism were of importance, because the predominant human metabolite was found to have synergistic anti-HCV activity [2].in vivo: Clemizole and reserpine treatment did not produce any modification of the dose-response curve to histamine [3].Clinical trial: Safety and Tolerability Study of Clemizole Hydrochloride to Treat Hepatitis C in Subject |
| 别名 | 克立咪唑;1-(p-chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole; 1-p-chlorobenzyl-2-(1-pyrrolidinylmethyl)benzimidazole; 1-p-chlorobenzyl-2-pyrrolidino-methylbenzimidazole; depocural; histacur; histakool; lergopenin; nsc 46261 |
克立咪唑
Clemizole （订货以英文为准）
编号：C125175
CAS号：442-52-4
分子式：C19H20N3CL
分子量：325.84
| 产品名称 | Clemizole |
| 中文名称 | 克立咪唑 |
| CAS号 | 442-52-4 |
| 分子式（M.F.） | C19H20N3CL |
| 分子量（M.W.） | 325.84 |
| 储存条件 | -20°C储存 |
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