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ARRY-380

ARRY-380 （订货以英文为准）

编号：A126334
CAS号：937265-83-3
分子式：C29H27N7O4S
分子量：569.63
货号 品牌 包装 目录价 您的价格 库存 数量 购买
A126334-5mg 阿拉丁 5mg ¥1225.90
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A126334-50mg 阿拉丁 50mg ¥7436.90
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A126334-10mg 阿拉丁 10mg ¥2011.90
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A126334-1mg 阿拉丁 1mg ¥350.90
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A126334-100mg 阿拉丁 100mg ¥11741.90
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A126334-25mg 阿拉丁 25mg ¥4022.90
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产品名称 ARRY-380
中文名称 ARRY-380
CAS号 937265-83-3
分子式（M.F.） C29H27N7O4S
分子量（M.W.） 569.63
储存条件 -20°C储存
溶解性DMSO 114 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
应用A potent, selective, small-molecule tyrosine kinase HER2 inhibitor
产品介绍这个产品是ARRY-380的类似物, ARRY-380是高活性HER2抑制剂，IC50为8 nM，对剪切型p95-HER2有相同的抑制性，比对EGFR的抑制性高500倍。
备注ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR. Phase 1.
生化机理ARRY-380 is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.
别名ARRY380; ARRY 380; 6-[5-[[[2-(甲磺酰基)乙基]氨基]甲基]-2-呋喃基]-N-[3-甲基-4-([1,2,4]三唑并[1,5-a]吡啶-7-氧基)苯基]-4-氨基喹唑啉;ARRY380;ARRY 380; 6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine
标识符号https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词Warning
危害声明H315-H319-H335
警示性声明P261-P305 + P351 + P338
个人防护设备dust mask type N95 (US), Eyeshields, Gloves
WGK德国3
搜索质检报告(COA)
搜索MSDS
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