| 熔点 | 270°C(lit.) |
| 别名 | ; |
5,6-二氨基-1-甲基尿嘧啶
5,6-Diamino-1-methyluracil （订货以英文为准）
编号：D155122
CAS号：6972-82-3
分子式：C5H8N4O2
分子量：156.14
| 产品名称 | 5,6-Diamino-1-methyluracil |
| 中文名称 | 5,6-二氨基-1-甲基尿嘧啶 |
| CAS号 | 6972-82-3 |
| MDL编码 | D155122 |
| 分子式（M.F.） | C5H8N4O2 |
| 分子量（M.W.） | 156.14 |
| 储存条件 | 2-8°C储存;避光;充氩 |
| Reaxys-RN | 127075 |
| 信号词 | Warning |
| 危害声明 | H315-H319-H335 |
| 警示性声明 | P261-P305 + P351 + P338 |
| 个人防护设备 | dust mask type N95 (US)， Eyeshields， Gloves |
| WGK德国 | 3 |
技术规格
| Background: | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. |
| Applications: | WB, IHC |
| Name of antibody: | RELB (Phospho-Ser573) |
| Immunogen: | Synthetic peptide of human RELB (Phospho-Ser573) |
| Full name: | v-rel reticuloendotheliosis viral oncogene homolog B (Phospho-Ser573) |
| Synonyms： | IREL; I-REL; REL-B |
| SwissProt: | Q01201 |
| IHC positive control: | Human breast carcinoma |
| IHC Recommend dilution: | 50-100 |
| WB Predicted band size: | 70 kDa |
| WB Positive control: | HUVEC cells untreated or treated with TNF |
| WB Recommended dilution: | 500-1000 |
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