| 熔点 | 115.0°C-119.0°C |
| 溶解性 | Soluble in DMSO (>25 mg/ml), ethanol (10 mg/ml), methanol (33.8 mg/ml), phosphate buffer (pH 4) (0.43 mg/ml) at 37 °C, water (partly miscible), chloroform, methylene chloride, and ethyl ether (slightly soluble). Insoluble in isopropanol. |
| 应用 | An α1- and β-adrenergic receptor antagonist. |
| 产品介绍 | Carvedilol是一种非选择性β/α-1受体抑制剂，用于治疗充血性心力衰竭和高血压。 |
| 生化机理 | Carvedilol is a AR (α1 and β-adrenergic receptor) antagonist with antioxidant properties. Studies show that the receptors α1D-AR and α1B-AR have a greater affinity for Carvedilol in comparison to the receptor β1-AR subtype. Carvedilol has been observed to block the oscillatory intracellular calcium changes induced by α1D-AR and α1B-AR, and shown to have a higher oxidative effect than Atenolol. The S(-) enantiomer of Carvedilol acts as a β-blocker, and the R(+) and S (-) enantionmers both block the α1. Carvedilol is an inhibitor of α1B-AR, β1-AR, β2-AR and α1D-AR. |
| 别名 | 卡维地洛;1-(9H-咔唑-4-氧基)-3-[2-(2-甲氧基苯氧基)乙基氨基]-2-丙醇1-?(9H-?Carbazol-?4-?yloxy)?-?3-?[[2-?(2-?methoxyphenoxy)?ethyl]?amino]?-?2-?propanol;BM-14190;BM 14190;BM14190 |
卡维地洛
Carvedilol （订货以英文为准）
编号：C123267
CAS号：72956-09-3
分子式：C24H26N2O4
分子量：406.48
| 产品名称 | Carvedilol |
| 中文名称 | 卡维地洛 |
| CAS号 | 72956-09-3 |
| 分子式（M.F.） | C24H26N2O4 |
| 分子量（M.W.） | 406.48 |
| 储存条件 | -20°C储存 |
| Reaxys-RN | 3918807 |
| 个人防护设备 | Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter |
| WGK德国 | 3 |
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